Longest Lasting Dry Mouth Lozenge with Complete Oral Hygiene
Patented Sustained Release Technology (SuRe®) Developed by Scientists and Dentists
Salese is a soft long lasting mint lozenge which continuously releases a natural ingredient which restores the moist mouth feel for hours in the mouth. An additional ingredient provide a fresh odor free mouth for the longest time by capturing odor causing compounds. Other ingredients kill and reduce bacteria in the mouth and neutralize acids from bacteria which causes tooth decay. Salese was developed by scientists who are experts in sustained release technology. They worked with dentists who are experts in dry mouth and oral hygiene.
In addition to Peppermint, Salese is available in Wintergreen and Lemon (Sensitive). Wintergreen essential oil is known to have anti-inflammatory benefits. Mild Lemon (Sensitive) is especially useful for moderate to severe oral inflammation where peppermint may be too strong.
As you move the lozenge around in the mouth, it slowly dissolves to release an ingredient to restore the moist mouth feel. The technology allows the incorporation of multiple ingredients to give a complete breath freshening and oral hygiene experience. Salese also has a natural ingredient to capture and eliminate odor causing sulfur compounds. Salese's continuous release of xylitol provides optimal reduction of bacteria; a xylitol candy lozenge gives a single dose of xylitol which is then ingested and thus not available for inhibiting bacterial growth. Peppermint is antibacterial, but only in sufficient amounts; only Salese provides this benefit. Bacteria secretes acids which causes cavities; only Salese provides an acid neutralizing natural ingredient. Only Salese provides added calcium for re-mineralizing tooth enamel.
"In my practice I treat a lot of patients suffering from xerostomia (dry mouth conditions), and over the years I have tried many different products with patients and have found few to be very effective. We have been using the Salese lozenges for over 6 years now and have found it to be one of the best products for treating xerostomia (dry mouth conditions) I have seen. It is especially attractive to patients because of its long lasting properties. Typically our patients tell us that the lozenges will last for many hours which is a big plus for them."

Dr. Anthony Dailley DDS

Center for Breath Treatment

WWW.BREATHCURE.COM
How Sustained Release (SuRe®) Technology Works in Salese
The scientists and dentists who created Salese realized that the only way to offer relief from dry mouth for hours and to provide a complete package for oral hygiene is if they provided continuous bathing of the mouth with the correct ingredients to handle the problems. The duration of a candy lozenge is too short to be effective. As a result, the scientists, who had 20 years of experience in sustained release technology, created the SuRe® Technology to make a lozenge which would last 1 to 4 hours in the mouth to effectively and continuously lubricate and moisturize the mouth and also provide oral hygiene, using multiple natural active ingredients.
The patented technology uses a matrix of the active ingredients in the form of a soft lozenge and holds it together with a cellulose polymer. All ingredients and polymer are edible. As one moves the lozenge around in the mouth, the surface layers of the matrix come off (dissolve), releasing the ingredients. This process continues until the lozenge has completely dissolved or the person decides to chew and eat the lozenge. This is shown below:
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For that moist mouth feel, Salese continuously releases xanthan gum for hours of dry mouth relief. In addition, for good breath, Salese has znic to capture volatile sulfur compounds from bacteria, the cause of bad breath. Reducing bacteria is also important for oral health and good breath. Salese has 2 natural ingredients to accomplish this: 1. Peppermint and other essential oils are used to both kill bacteria and provide that minty taste; 2. Xylitol is added to inhibit bacterial growth. For further oral hygiene, bicarbonate is added to neutralize acids generated by bacteria which cause cavities, and calcium is included to help re-mineralize teeth. No other lozenge offers these advantages. The formulation of Salese provides a very good tasting minty flavor that offers long lasting relief for dry mouth, freshens breath and offers excellent oral hygiene.
For people with dry mouth, oral health is a problem since there is insufficient saliva to wash away bacteria. Bacteria is the source of the problem for gum disease, tooth decay and bad breath. The role of bacteria is shown below:
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The SuRe® Technology not only offers the ability to release multiple ingredients, it offers the ability to deliver the correct amount of ingredients for the correct amount of time, as shown on the graph below:
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Advantages of Salese
Longest Lasting Relief of Dry Mouth!
Continuous release of xanthan gum to restore the moist mouth feel for hours. Patented Sustained Release (SuRe®) Technology ensures longest lasting dry mouth relief, flavor, fresh breath, and oral hygiene
No Need to Carry A Bottle of Mouth Rinse!
For relief, people with dry mouth often carry a bottle of mouth rinse. Salese eliminates this problem.
Hours of Fresh Breath!
Only lozenge with zinc which captures and eliminates Volatile Sulfur Compounds which cause bad breath. Others only mask bad breath with peppermint.
Kills More Bacteria!
Sustained release of xylitol results in lower bacteria in mouth for longer time Only Salese achieves levels of peppermint and other essential oils required to kill bacteria. Candy and other mints do not achieve these levels. Means Fresher Breath and better Oral Hygiene
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Neutralizes Mouth Acids!
Bacteria in mouth creates acids as it feeds on your food and snacks. Acids cause cavities. Bicarbonate in our lozenges neutralizes that acid. Study results below show change in acidity in worse case subjects with excessive dry mouth due to radiation therapy.
Click on Image for Larger View
Re-mineralizes Tooth Enamel!
Added calcium aids in re-mineralization of tooth enamel
Instructions for Using Salese
Use Salese anytime, anywhere for dry mouth relief
For best oral hygiene, use Salese following meals and snacks.
This prevents the drop in acidity of the mouth after any snack or meals which occur because you are also feeding bacteria when you eat and they produce acids, the cause of cavities.
Instructions
Remove Salese from the blister pack. The lozenge is soft so it is easier to break the foil from the back to remove the lozenge.
For best results, allow lozenge to dissolve in the mouth without biting or chewing. Occasionally move lozenge around as you would with any lozenge in the mouth. Alternatively, you may park the lozenge anywhere in your mouth.You may remove or chew the lozenge at any time. For maximal lozenge life and longest relief of dry mouth, don't bite or chew.
Salese Reviews
Unsolicited ratings and reviews from Amazon.com and Drugstore.com demonstrate the level of satisfaction of customers with this revolutionary new product.
Great Product
By JanG on August 12, 2014
Very good product. Helps a lot with dry mouth at night.
18 of 18 people found the following review helpful
Long lasting moisture
By Becky in Silicon Valley on September 7, 2011
Salese Wintergreen is the best dry mouth product I have found. No other has worked as well. I use the product because medications have caused my mouth to be dry and my dentist recommended it to prevent cavities. I have a friend with Sjogren's Syndrome and she has had great relief of dry mouth symptoms using Salese as well. It works a very long time.
7 of 7 people found the following review helpful
ONLY Product that Really Relieves Dry Mouth
By PK on November 29, 2012
Forget Bioteen and all others. These long-lasting tabs help my dry mouth. Plus they have lemon flavor as nice alternative to mint.
Four Stars
By Scott Bartnick on March 8, 2015
last forever
Helps with Chemotherapy side effect
By shirley f on July 6, 2014
I'm going through chemotherapy and Salese is a lifesaver for preventing mouth sores and restoring the pH in my mouth. Convenient and discreet, this can be used anywhere.
3 of 3 people found the following review helpful
Best dry mouth product there is
By Petra on February 15, 2014
I have the dreaded Sjogren's, a goofy name for a truly awful syndrome. Dry mouth is not only uncomfortable, over time it will ruin your teeth. Saliva is necessary to prevent decay, and without it it's only a matter of a few years before your teeth pay the price. I've tried every tab, spray, gel and rinse on the market. These tiny little discs do the trick in a way that no other product does. I'm not even sure why - but boy do they encourage my mouth to produce saliva. They are not marketed for overnight use, but that's what I use them for. I stick one between my gum and check and it usually lasts the majority of the night. I. Love. Them. Some nights I even have to swallow because I have saliva in my mouth. For those of you who don't realize how incredibly awesome that feeling is, count yourselves lucky. For those who do know what I'm talking about, please do yourself a favor and try these tabs at least once. Even if it ends up not being your thing, you don't want to leave any stone unturned when it comes to taking care of your dental health.
If you have dry mouth, you need Salese
By jakedaisy on October 30, 2013
Terrific product. Has made sleeping so much easier; no more dry mouth during the night! Absolutely wonderful. Thank you for having this!!!
5 of 5 people found the following review helpful
Dry mouth no more!
By DrOz "DrOz4u" on January 6, 2012
I ordered these for my wife after reading the reviews and I am happy to report that they have eliminated her dry dry mouth completely. She takes a sip of water and puts the lozenge in every other night before bed. I am glad I chose the lemon as she looked at the other flavors after the fact and said she would not have wanted to go to sleep tasting the other ones. Hope they help someone else out there.
5 of 5 people found the following review helpful
Dry Mouth comfort that lasts through the night
By astri ingrid sweet on November 23, 2011
Salese is the first dry mouth product that brings all night relief. It is still in my mouth when I wake up. It was a wonderful discovery.
11 of 11 people found the following review helpful
This really works
By cinminnesota on May 9, 2011
This is a great product. I have tried the lemon and mint flavors and prefer the lemon. It is sweetened with Xylitol, which actually lowers the risk of cavities. All other sugar substitutes and sugar will cause cavities, sometimes very quickly if your mouth is dry and you suck on something while sleeping. I'm a dental hygienist; I see it all the time. I have also tried Oramoist and Salese not only moistens my mouth better, it feels more comfortable. I just wish it were more widely available to people without internet access.
By AnnieOakley
from Michigan
describe yourself Brand Buyer
5.0Wow ! No more dry mouth !2/9/2015
Pros
Easy To Use
Effective
Cons
Best Uses
Try This When You Are Dry
Comments about Salese Sensitive, Hours of Dry Mouth Relief, Moisturizing Lozenges, Mild Lemon, 12 ea:

Salese is the most effective product I have ever used for dry mouth. I found it when I was taking a lot of medication and I swear by it. I just sent me cousin some because she was experiencing the same problem and she was amazed ...not to mention very grateful . So , try this product == you will not be disappointed.
Bottom Line Yes, I would recommend this to a friend
By Cautiousgirl
from Napa, CA
describe yourself Frequent User
4.0It works7/31/2013
Pros
Durable
Cons
Best Uses
Daily Use
Prevent Cavities
Comments about Salese Sensitive, Hours of Dry Mouth Relief, Moisturizing Lozenges, Mild Lemon, 12 ea:

I use it when I go to bed and believe it or not it lasts thru out the night.
Bottom Line Yes, I would recommend this to a friend
By Sue
from Bay area
5.0Excellent long lasting dry mouth relief12/30/2011
Pros
Easy To Use
Effective
Long lasting
Smells Great
Soothing
Cons
Best Uses
Cancer therapy
Daily Use
Diabetes
Dry mouth
Multiple prescription
med
Seniors
Sjogren's syndrome
Comments about Salese Sensitive, Hours of Dry Mouth Relief, Moisturizing Lozenges, Mild Lemon, 12 ea:

My father has been using this product for the last several years daily; sometimes during the day and religiously at night. It is the only product that has provided effective relief. I have sent it to relatives on chemotherapy who have also found it very effective. It is easy to use, has a great flavor, lasts for a long time and is very effective in keeping the mouth moist.
Bottom Line Yes, I would recommend this to a friend
By Marcy
from San Diego
describe yourself Budget Buyer
4.0Product was recommended by a friend.12/13/2011
Pros
For sensitive mouth
Really works
Works for almost 2 hours
Cons
Best Uses
Anytime
Daily Use
Men
Women
Comments about Salese Sensitive, Hours of Dry Mouth Relief, Moisturizing Lozenges, Mild Lemon, 12 ea:

This is sooooo much better than OraMoist and lasts waaaaaaaay longer then a gum, rinse, or spray. A buck less expensive would be great, but it is well worth it at the current price.
Bottom Line Yes, I would recommend this to a friend
Salese Value Proposition
The key value proposition for Salese is that it offers dry mouth relief for the longest period as compared to any other lozenge.

Users often report continuous relief for 3+ hours

The second value proposition is fresh breath and oral hygiene benefits of Salese
Other dry mouth lozenges cannot do this.

The Salese is less expensive on a time per use basis:

Salese lasts 1 to 4 hours, depending on how "active" you are in moving the lozenge around in the mouth. A box of Salese contains 12 lozenges. Each box of Salese lasts a minimum of 12 hours to 48 hours.
Questions & Answers About Salese
Q.
Why are there 3 flavors of Salese?
A.
Some people with very dry mouth are sensitive to the peppermint sensation in their mouth. For those persons, Nuvora offers the Wintergreen Salese and the very mild Lemon Salese, designed specifically for the sensitive mouth.
Q.
What are the key ingredients in the lozenges?
A.
All of our lozenges are formulated with specific needs of the end user benefits in mind. While many ingredients are shared between many of our products, they are specifically formulated to achieve desired results. For ingredients refer to the Ingredient List for each of our products.
Q.
Do the lozenges stain teeth?
A.
No. Our lozenges are perfectly safe for daily use and they do not stain your teeth.
Q.
How many lozenges can be used during a day?
A.
In most cases 1 to 2 lozenges per day, after meals or snacks, along with regular brushing and flossing, will be sufficient to maintain good oral care. Salese users may require more based on their individual symptoms.
Q.
Are the products safe for children?
A.
Due to the small size of the lozenge it may present a choking hazard for small children. Please, use all necessary precautions and keep the lozenges away from small children. For older children the lozenges are safe to use.
Q.
Are there any contra-indications or cautions?
A.
All ingredients in our lozenges are FDA approved as food items and are GRAS (Generally Recognized As Safe). We are not aware of any contra-indications or necessary precautions that should be taken. If you think you are having any negative effect, discontinue using the lozenges immediately and consult with your physician.
Q.
Is it Ok to bite or chew the lozenges?
A.
Although the lozenge is designed to rest in the mouth, it is perfectly safe to bite or chew the lozenge. The ingredients will be released in a very short period of time and you may notice a sudden burst of flavor in the mouth.
Q.
What if the lozenge breaks apart?
A.
In some cases the lozenge may start to break apart towards the end of the usage time. You may chew, swallow or spit the pieces out. All of the ingredients in our lozenges are FDA approved as food items and are GRAS (Generally Recognized As Safe). Please note, that lozenges breaking apart is not a product defect, but can happen when the structure of the lozenge wears thin.
Q.
What is unique about the lozenge?
A.
Unlike toothpaste or mouth rinse, the lozenges release the beneficial ingredients over an extended period of time. As a result, they kill more bad breath bacteria and eliminates volatile sulfur compounds which causes bad breath.
Q.
How do the lozenges work?
A.
As the lozenge is moved around in the mouth the beneficial ingredients are released. The more frequently the lozenge is moved around the more rapid the ingredients are released. Conversely, the less the lozenge is moved around the slower the ingredients are released.
Q.
How long do the lozenges last?
A.
The lozenges are designed to last about an hour. Based on how frequently the lozenge is moved around in the mouth it may last a little longer or shorter. Anything plus or minus 15 minutes is still considered to be optimal.
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References and Research
Nuvora Research

J.B. Gin, "Sustained Delivery to the Oral Tissues," Drug Delivery & Development, Vol 11, No. 5, p. 52, June 2011

B. Shipman, "Saliva Modification in Radiation Therapy," 57th Meeting American Academy of Maxillofacial Prosthetics, Oct 31 - Nov 3, 2009

O. Kharevich, B. Shipman, B.M. Goldman, M. Nahon, "Salese to Buffer Saliva in Elderly Patients with Xerostomia: a Pilot Study," Journal of prosthodontics, Vol 20, No. 2, pages 135-138, February 2011

P. Reichmann, B, M.T. Rechmann, M.L. Rapozo-Hilo, F. Kohinke, "In-vivo Fluoride Release from Nuvora-F-Lozenges into Saliva," Journal of Dental Research, Barcelona Meeting, July 14, 2010

F. Kohinke, "When you Cannot Brush and Floss…," Inside Dentistry, July/August, 2007, p.2
References for Ingredients
Xanthan Gum as Saliva Substitute

A Preetha and R. Banerjee, "Comparison of Artificial Saliva Substitutes," Trends Biomatter. Artif. organs, vol 18 (2), pages 178-186, January, 2005.

W.A. van der Reijden, A Vissink, E.C.I. Veerman, A.V.N. Amerongen, "Treatment of Oral Dryness Related Complaints (Xerostomia) in Sjogren's Syndrome," Annals Rheumatic Disease, vol 58, Pages 465-474, 1999.

Zinc and Volatile Sulfur Compounds and Bad Breath

A. Young, G Jonski, G Rolla, "Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride - effect of concentration," European Journal of Oral Sciences, Volume 111, Issue 5, pages 400-404, October 2003

A. Young, G Jonski, G Rolla, "the oral anti-volatile Sulphur compounds effects of zinc salts and their stability constants," European Journal of Oral Sciences, Volume 110, Issue 1, pages 31-34, Feb 2002

Anti-bacterial and Anti-viral Effects of Essential Oils

Imai H, et al. "Inhibition by the essential oils of peppermint and spearmint of the growth of pathogenic bacteria." Microbios 106 Suppl 1 (2001): 31-39

Mimica-Dukit N, et al. "Antimicrobial and antioxidant activities of three Menthe species essential oils." Planta Medica 69.5 (May 2003): 413-419.

Schuhmacher A, Reichling J, and Schnitzler P. "Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus type 1 and type 2 in vitro." Phytomedicine: International Journal Of Phytotherapy And Phytopharmacology 10.6-7 (2003): 504-510.

Caubet, R., Pedarros-Caubet, F., & Ellison, W. (2008, October). The Quantitative Assessment of Antimicrobial Agents: Subinhibitory Concentrations of Eucalyptus globulus Essential Oil against Staphylococcus aureus. Pharmaceutical Biology, 46(10/11), 738-745.

Takarada, K., et al. "A comparison of the antibacterial efficacies of essential oils against oral pathogens," Oral Microbiology & Immunology 19.1 (Feb. 2004): 61-64.

V. Shapiro, S., A. Meier, and B. Guggenheim. "The antimicrobial activity of essential oils and essential oil components towards oral bacteria." Oral Microbiology & Immunology 9.4 (Aug. 1994): 202-208.

Xylitol and Bacterial Inhibition

B. Burt, "The use of sorbitol-and Xylitol-sweetened chewing gum in caries control," J. Am. Dental Assoc. Vol. 137, February 2006.

W. Edgar, "Sugar substitutes, chewing gum and dental caries - a review," British Dental J. Vol. 184, No. 1, 1998.

P. Milgrom, et al. "Mutans Streptococci Dose Response to Xylitol Chewing Gum," J. Dental Research. Vol. 85, No. 2. 2006

Bicarbonate Effect on Oral Acidity

B. Shipman, "Saliva Modification in Radiation Therapy," 57th Meeting American Academy of Maxillofacial Prosthetics, Oct 31-Nov 3, 2009

O. Kharevich, B. Shipman, B.M. Goldman, M. Nahon, "Salese to Buffer Saliva in Elderly Patients with Xerostomia: a Pilot," Journal of prosthodontics, Vol 20, No. 2, pages 135-138, February 2011

J.C. Blake-Haskins, et al. "The effect of bicarbonate/fluoride dentifrices on human plaque pH."The Journal Of Clinical Dentistry 8.6 (1997): 173-177